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Development of Exenatide: An Incretin Mimetic Exenatide (Exendin-4) Synthetic version of salivary protein found in the Gila monster Approximately 50% identity with human GLP-1 Binds to known human GLP-1 receptors on cells in vitro Resistant to DPP-IV inactivation DOSAGE AND ADMINISTRATION Inject subcutaneously within 60 minutes prior to morning and evening meals (or before the two main meals of the day, approximately 6 hours or more apart

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Plant Cell 10 , 11351149 (1998)

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