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Some people may transition to other therapies or focus more on diet and exercise

Lingvay I, Mosenzon O, Brown K, et al

Beyond the Pancreas: Contrasting Cardiometabolic Actions of GIP and GLP1

To counteract this physiological mechanism, new forms of GLP-1 receptor agonists (GLP-1RAs) have been designed to oppose the breakdown by DPP-4[3]

Other life-threatening diseases caused by the problem of obesity: Cardiovascular Disease: Triples the risk of heart disease and increases the likelihood of hypertension and stroke

While those taking semaglutide (Wegovy) and tirzepatide (Mounjaro) lost double the amount of weight compared with people using older jabs 16kg on average patients put on 9.6kg within a year, meaning they could expect to regain all 16kg again in just over 20 months