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Cigarette smoking remains the leading cause of preventable disease, disability, and death in the United States, accounting for more than 480,000 deaths every year, or about 1 in 5 deaths

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ADHD prevalence is generally higher among males than females, potentially reflecting increased susceptibility of the male nervous system to nicotine exposure or sex-related hormonal differences influencing neurotransmitter regulation 35

In the model 1, which adjusts for no covariates, the total testosterone was increased by 0.10 (0.06, 0.14) for each additional unit of serum cotinine

and is used more as an amusement, or an assistant for guzzling [alcohol], than for any good expected from it. 20 Clarke, A Dissertation on the Use and Abuse of Tobacco, 11