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Abstract Maintenance of skeletal muscle mass throughout the life course is key for the regulation of health, with physical activity a critical component of this, in part, due to its influence upon key hormones such as testosterone, estrogen, growth hormone (GH), and insulin-like growth factor (IGF)

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Hypothemycin, one of the resorcylic acid lactones, is a representative inhibitor targeting cysteine residues located in the ATP site of Ser/Thr/Tyr protein kinases