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doi: 10.1038/s41587-020-0546-8

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Conversely, with conditions leading to neurodegeneration or chronic inflammation, oxidative stress persists long enough to lead to abnormal immune response pathwaysparticularly NF-kband prolonged treatment with GSH may lead to reduced redox tone and thus attenuating NF-kB, causing an anti-inflammatory response instead of an immuno-supportive one (Limongi et al., 2019

Equally important is physician oversight

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In most cases, confirming whether its a flare and not drug side effects will require medical evaluation, such as blood work, stool tests like a fecal calprotectin test, or an endoscopy, he says