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In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health

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The diagnosis is based on the finding of cysteinylglycinuria and decreased activity of dipeptidase, and is established by: Increased urinary excretion of cysteinyl glycine Normal concentration of cysteinyl glycine in plasma Low activity of dipeptidase in cultured skin fibroblasts and/or red blood cells

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