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Because results from prospective trials are limited by low statistical power, and because retrospective studies are often subject to bias, a pooled analysis of phase III clinical trials and two endpoint trials was performed

(PubMed) Penberthy WT, Kirkland JB

This raises concerns about how online environments shape conversations with providers and influence treatment seeking behaviors. Further research can inform guidance to improve communication and ensure appropriate usage of GLP-1 drugs

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These direct effects are further supported by human studies demonstrating the wide expression of GLP-1 receptors in the proximal tubules, juxtaglomerular cells, hilar and intralobular arteries, and preglomerular vascular smooth muscle cells [49]