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If your protocol calls for a 0.5mg dose and you've mixed incorrectly, you could be administering 1.25mg or 0.2mg instead

Variations of serum oxidative stress biomarkers under first-line antituberculosis treatment: a pilot study

Furthermore, it may also be due to the possible synergy between these medications and chemotherapy or targeted therapies, although this has only been shown in non-neuroendocrine neoplasms