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[DOI] [PMC free article] [PubMed] [Google Scholar] Shalata A, Mittova V, Volokita M, Guy M, Tal M

If you are concerned about getting every last unit out of a vial, they are worth the small extra investment

For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc (Sxc ), present in astrocytes, and EAAT3 present in neurons

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Subcutaneous injections also bypass the digestive system, so absorption is high

In a previous Phase I trial, six patients treated with a single dose of NTLA-2001 showed significant reductions in serum TTR protein levels, with no serious adverse effects or liver damage reported