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Anti-inflammatory and anti-fibrotic mechanisms Although retatrutide treatment resulted in pronounced weight loss, prior studies have shown that obesity-associated immune, metabolic, and fibrotic signatures in epididymal adipose tissue can persist despite substantial weight loss, indicating that adipose tissue remodeling cannot be fully explained by weight loss [38, 39]

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This may lead to less effective results for muscle growth and recovery

The inactive thyroid hormone must be converted to triiodothyronine, T3, the active thyroid hormone in order to be used by the cell

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The treatment given to this patient resulted in an improved microbiome with an increase in bacterial diversity, partly due to an increase in the relative abundance of butyrate-producing bacterial species, which were paralleled by an increase in butyrate concentration, an anti-inflammatory SCFA (Engen et al., 2020)