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Adv Biomed Res

Animal Model:8-10 male C57BL/6J mice [1] Dosage:50 mg/kg Administration:i.p., a single dose for 28 or 12 days Result:Displayed a more oxidative muscle phenotype, increased the complex I (NDUFB8) and complex V (ATP5A) protein expression in the gastrocnemius muscle and cytochrome C, mitochondria content and oxidative type IIa muscle fibers lavels in mice

Although all three GLP-1 analogs tended to suppress muscle mass as similar manner, tirzepatide showed the biggest body weight reduction similar with clinical study

Noticeable weight loss results typically take several weeks of consistent treatment combined with a healthy diet and exercise plan

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Biologic therapies that target specific disease mediators have become a mainstay in the treatment of moderate-to-severe disease, whereas advances in the treatment of mild-to-moderate disease have been limited