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The second registered study, REDEFINE, is a phase 3 trial evaluating the combination therapy of cagrilintide and semaglutide, known as CagriSema, to achieve weight loss in people with excess body weight and T2D

The precise contribution of glucagon receptor activation to addiction-related outcomes remains an active area of investigation, with early preclinical work suggesting it may enhance the effects achieved through GLP-1 and GIP alone

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