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The hyper-inflammatory response caused by SARS-CoV-2 induces the process of immunosenescence, increases endothelial cell damage, and leads to myofibrillar degradation and muscle wasting (sarcopenia) due to mitochondrial dysfunction and autophagy [102]

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Physical activity [2], nutrition therapy [3], self-management education and support [4], and weight management [5] are other important components of glycemic management for type 2 diabetes, and are discussed in their own chapters

[104] [105] Deficiency does not develop if dietary intake of vitamin B 12 is adequate or prophylactic B 12 supplementation is given

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