[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care
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The probiotic Akkermansia muciniphila has been promoted for blood sugar and appetite control, possibly by increasing GLP-1, that same satiety hormone targeted by medications like semaglutide (Ozempic)
a figure that many patients on GLP-1 therapy fall short of, partly because the appetite suppression the medications produce makes hitting protein targets without conscious effort difficult. Clinical note Patients on GLP-1 therapy frequently report that protein-rich foods (particularly meat and eggs) become less palatable during treatment
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7d) and expression of NF-B target genes, including c-FLP , c-IAP , and MnSOD (Fig