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Both involve a gradual dose-escalation process

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The Beckman Coulter AU480 clinical chemistry analyzer was used in combination with appropriate reagents (ALT, AST, TG, cholesterol, LDL, and HDL), calibrators (Beckman Coulter Lyophilized Chemistry Calibrator levels 1 and 2), and quality control materials (Bio-Rad Liquid Assayed Multiqual levels 1 and 3)

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New England Journal of Medicine, 387(3), 205-216

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