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While they are used in the same way (placed under the upper lip), they are made from different ingredients

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[notes 12] [12] Some e-cigarette products had acrolein identified in the e-cigarette vapor, at greatly lower amounts than in cigarette smoke

At 52 weeks, 23% of Varenicline users remained smoke-free (compared to 15% for bupropion and 10% for placebo)

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