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Although L-cells are classically described as endocrine cells, like enterochromaffin cells (Bellono et al., 2017), they can synapse directly with peripheral afferent and efferent neurons (Bohrquez et al., 2015), providing a direct neural pathway for bi-directional brain-gut communication (Kaelberer et al., 2018)
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If you recently titrated up to a higher dose and your constipation dramatically worsened, that dose increase is likely the primary driver
While alcohol intoxication may initially make a person feel drowsy and fall asleep faster, it can also lead to more frequent awakenings during the night and difficulty falling back asleep (sleep-maintenance insomnia)
This is why a targeted approach is so important