Intended Use: Laboratory research use only
Pegvisomant is more costly than SRL, and daily injection is required
This difference is likely to be related to the more tightly packed ECD interface of RAMP2 and CTR, driven by the interactions with P37 Cagri , and the preferential CTR engagement by Cagri via a bypass conformation, as discussed below in the context of CTR complexes
Modulation of transforming growth factor-beta (TGF-beta), integrins, and stem cell pathways have also been observed
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