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In this study, obese men underwent an initial 8-week low-calorie diet (very low calorie, ~800 kcal/day), losing on average 16.5 kg (about 15% of body weight) pubmed.ncbi.nlm.nih.gov

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Endocr Pract 19(Supplement 2):148 Glaesner W, Mark Vick A, Millican R, Ellis B, Tschang SH, Tian Y, Bokvist K, Brenner M, Koester A, Porksen N (2010) Engineering and characterization of the longacting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein