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You have to be fully aware of the evidence gaps that exist

Located at key interfaces, including the BBB, meninges, and perivascular spaces, mast cells are uniquely positioned to detect environmental stressors and rapidly respond by releasing a potent cocktail of mediators such as histamine, tryptase, cytokines, and prostaglandins

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Measuring these markers may help detect early immune dysregulation in at-risk women 262

J., Leighton, B

This is particularly relevant after rotator cuff repair surgery, where the quality of tendon-bone healing directly determines whether the repair holds or retears