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They also decline with metabolic stress, obesity, and high-fat diets

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1 With patent challenges to branded GLP-1 products advancing across multiple jurisdictions and demand for affordable obesity and diabetes therapies continuing to grow, the generic entry raises practical questions for the broader GLP-1 commercial ecosystem: how It is estimated 589 million adults are currently living with diabetes worldwide a number projected to reach 853 million by 2050 underscoring the scale of the patient population these therapies stand to reach

Western blot assay Cells (1 10 6 ) were grown to 7080% confluency and treated with DMSO control, (1S,3R)-RSL3 (RSL3, Catalog # 19,288, Cayman Chemical, MI) or Fer1 (Medchemexpress, NJ) as per the experiments