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Cell proliferation assays For cell proliferation assays, cells were seeded at a density not lower than 10,000 cells/cm 2 to avoid culture loss of patient-derived NPs

Both drugs were generally well-tolerated, with similar profiles of mild-to-moderate side effects such as nausea, diarrhea and vomiting

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No major drug interactions have been identified, though gastrointestinal effects may occasionally affect absorption of other oral medications

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