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Prescription drugs such as semaglutide directly activate GLP-1 receptors, while tirzepatide activates both GIP and GLP-1 receptors

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J.ZhangS.JohnsonC.KimberC.et al (2016)

For chronic pain patients, Lyrica can be a good, non-opioid option

On the other hand, it reduces the amount of Proteobacteria, which is more abundant in obese individuals